Biomolecules | Free Full-Text | SIRT1 and SIRT2 Modulators: Potential Anti-Inflammatory Treatment for Depression? | HTML
Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects
Effects of SIRT1 and SIRT2 inhibitors on renal fibroblast... | Download Scientific Diagram
Anticancer Effects of a New SIRT Inhibitor, MHY2256, against Human Breast Cancer MCF-7 Cells via Regulation of MDM2-p53 Binding
Structures of SIRT1 inhibitors EX-527 and its analogue Compound 35,... | Download Scientific Diagram
Sirtuin 1 and oral cancer (Review)
Mechanisms and disease implications of sirtuin-mediated autophagic regulation | Experimental & Molecular Medicine
Frontiers | Dual Tumor Suppressor and Tumor Promoter Action of Sirtuins in Determining Malignant Phenotype
CSAG2 is a cancer‐specific activator of SIRT1 | EMBO reports
Activation of silent information regulator 1 exerts a neuroprotective effect after intracerebral hemorrhage by deacetylating NF‐κB/p65 - Deng - 2021 - Journal of Neurochemistry - Wiley Online Library
Frontiers | Human Sirtuin Regulators: The “Success” Stories
NAD+-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease: Cell Metabolism
Selisistat - an overview | ScienceDirect Topics
PDF) An Exploratory Double blind, Randomised Clinical Trial with Selisistat, a SirT1 Inhibitor, in Patients with Huntington's Disease.
Recent advances in inhibitors of sirtuin1/2: an update and perspective | Future Medicinal Chemistry
Frontiers | Brain SIRT1 Mediates Metabolic Homeostasis and Neuroprotection
Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions | PLOS ONE
The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop | PNAS
Sirtuin Inhibition: Strategies, Inhibitors, and Therapeutic Potential: Trends in Pharmacological Sciences
Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1* - Journal of Biological Chemistry
A potent and selective small molecule inhibitor of sirtuin 1 promotes differentiation of pluripotent P19 cells into functional neurons | Scientific Reports
Pharmacological Advantage of SIRT2-Selective versus pan-SIRT1–3 Inhibitors | ACS Chemical Biology
The effects of Sirt1 pharmacologic activation and inhibition on... | Download Scientific Diagram
The Critical Role of SIRT1 in Parkinson's Disease: Mechanism and Therapeutic Considerations
Full article: Two novel SIRT1 activators, SCIC2 and SCIC2.1, enhance SIRT1-mediated effects in stress response and senescence
